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Hypospadias information

Physical and Psychological Effects Of Hypospadias (Chapter 1 part 1)

Physical and Psychological Effects Of Hypospadias
Author: Dominique Salm (2003)

Chapter 1: General information about hypospadias 

INTRODUCTION

This is a theoretical research paper on the psychological consequences of hypospadias, a male congenital deficiency of the urethra. The term hypospadias refers to the urethral meatus, or opening, which instead of being located at the tip of the penis is found somewhere along the ventral side of it. There are different degrees of severity of hypospadias. In the least severe cases the urethral opening is located just below the glans of the penis; in the most severe cases the opening is found at the base of the penis close to the perineum.

The vast majority of literature concerning hypospadias is found in the medical domain, primarily in surgical and pediatric urology, but also in the field of endocrinology. Hypospadias is one of the most common congenital malformations in boys and men, and consequently there are a great many articles which discuss its correction by surgery as well as its physical etiology.

My interest in approaching the subject of hypospadias in a psychology thesis stems, in part, from the fact that there is hardly any data on this issue in French literature in the area of human sciences, and the field of psychology in particular.  

My objective is to contribute a modest advancement in this field. Since we know that hypospadias affects almost one man in 125 – according to the latest estimates – it seems important to explore the possible reasons for the relative silence surrounding the condition.  

And since hypospadias affects one of the most personal parts of the male anatomy, how could it not have psychological repercussions? How could this condition only relate to the physical aspects? As a future psychologist, it seems very relevant to me to explore these questions more deeply.

In all honesty, however, even before commencing this research I had some idea of the kind of answers which might be found in answer to these two questions. Being personally affected by the issue, I’m already aware that hypospadias is a psychological condition as well as a physical one, and that it is not easily approachable.

The difficulty in finding information about hypospadias, along with the lack of opportunities for discussing it, has for many years left me perplexed. For a long time I have been asking myself not only what the causes of hypospadias could be, but also whether I would ever have the opportunity to meet other people in the same situation.

I must add that as well as trying to find articles or research studies on the consequences of hypospadias, my approach has been towards lifting the veil which conceals this condition. And the title of this thesis tries to reflect how much men with hypospadias wish to better understand the impact of hypospadias both on ourselves and on others.

You may wonder why a psychology thesis with these aims comprises two chapters on the medical aspects concerning hypospadias and only one chapter concerning its psychological, psychosocial and psychosexual consequences. I believe it’s extremely useful to offer people with little knowledge of the subject some information on the various data available – embryological, anatomical, etiological and epidemiological – and also some information on the surgical treatment of hypospadias. Why is this?

First, the medical aspects of hypospadias represent the greater part of the available literature. And the medical literature can be very useful, for example in better understanding the origins of hypospadias.

In recent years, many epidemiological and eco-toxological studies have suggested that hypospadias might be increasing in many industrialized countries. There may be a link to our modern lifestyle, particularly to many forms of environmental pollution, which may influence vital hormonal processes such as the production of male hormones (androgens) during the embryo’s sexual differentiation, contributing to the malformation of the external male sex organs.

Second, as well as helping us to understand the etiology of hypospadias, the medical literature describes the physical consequences of hypospadias and the effect it has on urination and sexual activity.

I regard it as important to review work in the fields of pediatric urology and surgery to see which surgical techniques have been adopted as best practice in this field, and to consider both the resulting quality of surgical reconstructions of the urethra and the psychological impact of this type of surgery.

This thesis is divided into three chapters. The first chapter presents some general reflections on hypospadias, the second chapter reviews the issues around surgical treatment of hypospadias, and the third chapter is devoted to the psychological, psychosocial and psychosexual issues associated with hypospadias.

In the first chapter I start by defining hypospadias, and then present data related to embryology, anatomy, medical classification, and the etiology and epidemiology of hypospadias.

In the second chapter, I discuss the surgical treatment of hypospadias. I consider the the objectives and principles of surgery in this field and review the physical consequences of such surgery. I also present a historical review of hypospadias surgery. In addition, I explore the issues surrounding the optimum age for surgery, surgical techniques currently utilized, inherent complications in this type of surgery and finally, pre- and post-operative care.

In the third chapter, I present three psychological studies on hypospadias. Two of these are quantitative in nature and one is qualitative. After reviewing the focus of these studies, I consider the principal results and the implications of this research for people with hypospadias and their families.

Chapter 1: General Considerations About Hypospadias

1. Introduction

The first chapter of this thesis presents a selection of knowledge and discoveries concerning hypospadias drawn from medical research across several disciplines. Initially, however, I present several definitions of hypospadias drawn from both normal and more specialized dictionaries: some aspects of these definitions will be considered in more detail elsewhere in this thesis.

Next, I review the embryological development which leads to formation of the genito-urinary tract, with particular emphasis on the development of the male fetus; this serves as a background to the embryological origins of hypospadias.

Then, I review the anatomical aspects of hypospadias and describe the various forms it can take. As we shall see, the diversity of hypospadias has resulted in the creation of special classification systems. In addition, I have approached the question of the etiology of hypospadias.

To this end, I propose a joint view of the principal etiological hypotheses to be found in literature, taking into account many possible factors: hereditary, genetic, endocrinal and environmental.

Finally, the first chapter ends with some epidemiological data on hypospadias, which demonstrates the frequency and incidence of this condition.

2. Definitions

2.1. Etymology
Etymologically, the term hypospadias is derived from the Greek hupo, meaning ‘under’ and spaô, a ‘fissure’ or ‘crack’.

2.2. Everyday Definitions
Firstly we can note a few definitions from different everyday dictionaries.  The definition of hypospadias given by Le Petit Larousse (2003), is relatively short: ‘Malformation of the penis in which the urethra opens on the inferior side and not at the extremity.’ 

Le Petit Robert (2003), defines hypospadias as follows: ‘Malformation of the urethra, characterized by a urinary meatus situated on the inferior side of the penis or even at the level of the perineum.

2.3. Specialized Definitions
Other more specialized dictionaries also offer us information as to the meaning of the word.
The Dictionnaire des Termes de Médecine (Garnier & Delamare, 2000) gives an anatomical definition: ‘Malformation of the male urethra, characterized by the division, to a greater or lesser extent, of the inferior wall, with an abnormal orifice situated at a variable distance from the extremity of the organ.’

The definition from the Larousse Médical (2003) seems more descriptive : ‘Congenital malformation in which the urethral meatus (external opening of the urethra) is situated on the inferior side of the penis. A malformation of the prepuce, absent on the anterior side is always associated with hypospadias. The urethral meatus may open at different levels of the urethra. Hypospadias is known as glanular when it opens under the glans, penile when it opens in the middle of the penis and peno-scrotal when it opens at the junction of the penis and scrotum.’

In Le Dictionnaire des Maladies, for the use of health professionals (Prudhomme & d’Ivernois, 2002), still more information can be drawn from the definition: ‘Malformation of the urethra, very common (affects one boy in 300), characterized by a malpositioning of the opening of the urinary meatus which is situation further back on the glans, on the inferior side of the penis or at the junction of the penis and scrotum. Chordee is often associated. Treatment is surgical and gives excellent results.’

Most of the knowledge about hypospadias resides in the specialized medical field of surgery and pediatric urology.  I quote, for example, the definition offered by De Sy & Hoebeke (1996, p.158) : ‘Congenital anomaly of the penis which results in an incomplete development of the anterior urethra. A hypospadias is characterized by the degrees of deficiency of the urethra and of the corpus spongiosum and the corpus cavernosa.’

I will expand the various aspects of hypospadias implied in the above definitions through a review of the medical literature on hypospadias. I will center my subject matter on the many relevant elements, namely: the embryogenesis of the penis and urethra, anatomical knowledge of hypospadias, etiological hypotheses, epidemiological data and treatment by surgery.

Continued here.

Hypospadias review - bibliography

Bibliography of Hypospadias Review Above

BIBLIOGRAPHIE 

Articles used in the review

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Morgan, J.F., & Mezey, G.C. (1999). Surgery experienced as sexual abuse: A case of pre-pubescent sexual offending and hypospadias. Clinical Child Psychology and Psychiatry, 4, 543-550.

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Mureau, M.A.M., Slijper, F.M.E., van der Meulen, J.C., Verhulst, F.C., & Slob, A.K. (1995). Psychosexual adjustment of men who underwent hypospadias repair: a norm-related study. Journal of Urology, 154, 1351-1355.

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Mureau, M.A.M., Slijper, F.M.E., Nijman, R.J.M., van der Meulen, J.C., Verhulst, F.C., & Slob, A.K. (1995b). Psychosexual adjustment of children and adolescents after different types of hypospadias surgery: a norm related study. Journal of Urology, 154, 1902-1907.

Mureau, M.A.M., Slijper, F.M.E., Slob, A.K., Verhulst, F.C., & Nijman, R. (1996). Satisfaction with penile appearance after hypospadias surgery: the patient and the surgeon’s view. Journal of Urology, 155, 703-706.

Mureau, M.A.M., Slijper, F.M.E., Slob, A.K., & Verhulst, F. (1997). Psychosocial functioning of children, adolescents, and adults following hypospadias surgery: a comparative study. Journal of Pediatric Psychology, 22, 371-387.

North, K., Golding, J., & the ALSPAC Study Team (2000). A maternal vegetarian diet in pregnancy is associated with hypospadias. British Journal of Urology International, 85, 107-113.

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Paparel, P., Mure, P.Y., Garignon, C., & Mouriquand, P. (2001). Translation urétrale de Koff : à propos de 26 hypospades présentant une division distale du corps spongieux. Progrès en Urologie, 11, 1327-1330.

Paulozzi, L.J. (1999). International trends in rates of hypospadias. Environmental Health Perspectives, 107, 4, 297-302.

Paulozzi, L.J., Erickson, D.J., & Jackson, R.J. (1997). Hypospadias trends in two US surveillance systems. Pediatrics, 100, 5, 831-834.

Perovic, S.V., Scepanovic, D.R., Vukadinovic, V.M., Djakovic, N., & Djordjevic, M.L.J. (1999). Technique de désassemblage du pénis: une nouvelle approche de la chirurgie reconstructrice de l’hypospade. Progrès en Urologie, 9, 371-379.

Pierik, F.H., Burdof, A, Nijman, J.M.R., de Muinck Keizer-Schrama, S.M.P.F., Juttman, R.E., & Weber, R.F.A. (2002). A high hypospadias rate in The Netherlands. Human Reproduction, 17, 1112-1115.

Preves, S.E. (1999). For the sake of the Children: destigmatizing intersexuality. In A.D. Dreger (Ed.), Intersex in the age of ethics (pp. 51-65). Hagerstown, Maryland: University Publishing Group.

Ravasse, P., Petit, T., & Delmas, P. (2000). Hypospadias antérieur: Duplay ou Mathieu ? Progrès en Urologie, 10, 653-656.

Reiner, W.G. (1999). Psychosexual dysfunction in males with genital anomalies: Late adolescence, Tanner stages 4 to 6. Journal of the American Academy of Child and Adolescent Psychiatry, 38, 865-872.

Richter, F., Pinto, P.A., Stock, J.A., & Hanna, M.K. (2003). Management of recurrent urethral fistulas after hypospadias repair. Urology, 61, 448-451.

Rittler, M., & Castilla, E.E. (2002). Endocrine disruptors and congenital anomalies. Cadernos de Saúde Pública, 18, 421-428.

Roberston, M., & Walker, D. (1975). Psychological factors in hypospadias repair. Journal of Urology, 113, 698, 700.

Sandberg, D.E., Meyer-Balbhurg, H.F.L., Aranoff, G.S., Sconzo, J.M., & Hensle, T.W. (1989). Boys with hypospadias: a survey of behavioral difficulties. Journal of Pediatric Psychology, 14, 491-514.

Sandberg, D.E., Meyer-Bahlburg, H.F.L., Yager, T.J., Hensle T.W., Levitt, S.B., Kogan, S.J., & Reda, E.F. (1995). Gender development in boys born with hypospadias. Psychoendocrinology, 20, 693-709.

Sandberg, D.E., Meyer-Bahlburg, H.F.L., Hensle, T.W., Levitt, S.B., Kogan, S.J., & Reda, E.F. (2001). Psychosocial development of middle childhood boys with hypospadias after genital surgery. Journal of Pediatric Psychology, 26, 465-475.

Sanders, C. (2002). A review of current practice for boys undergoing hypospadias repair: from pre-operative work up to removal of dressing post-surgery. Journal of Child Health Care, 6, 60-69.

Santti, R., Makela, S., Strauss, L., Korkman, J., & Kostian, M.L. (1998). Phytoestrogens: potential endocrine disruptors in males. Toxicology and Industrial Health, 14, 223-237.

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Searles, J.M., & Mackinnon, A.E. (2001). The ‘SANAV’ hypospadias dressing. British Journal of Urology International, 87, 531-533.

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Senkul, T., Karademir, K., Iseri, C., Erden, D., Baykal, K., & Adayener, C. (2002). Hypospadias in adults. Urology, 60, 1059-1062.

Shankar, K.R., Losty, P.D., Hopper, M., Wong, L., & Rickwood, A.M.K. (2002). Outcome of hypospadias fistula repair. British Journal of Urology International, 89, 103-105.

Sharpe, R.M. (2003). The estrogen hypothesis – where do we stand now? International Journal of Andrology, 26, 2-15.

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Silver, R.I., & Russel, D.W. (1999). 5-alpha-reductase type 2 mutations are present in some boys with isolated hypospadias. Journal of Urology, 162, 1142-1145.

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Snodgrass, W.T. (1994). Tubularized incised plate urethroplasty for distal hypospadias. Journal of Urology, 151, 464.    

Snodgrass, W.T. (1999). Tubularized incised plate hypospadias repair: Indications, technique, and complications. Urology, 54, 6-11.  

Snodgrass, W.T., & Lorenzo, A. (2002a). Tubularized incised plate urethroplasty for proximal hypospadias. British Journal of Urology International, 89, 90-93.

Snodgrass, W.T., & Nguyen, M.T. (2002b). Current technique of tubularized incised plate hypospadias repair. Urology, 60, 157-162.

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Toppari, J., Haavisto, A.M., & Alanen, M. (2002). Changes in males reproductive health and effects of endocrine disruptors in Scandinavian countries. Cadernos de Saúde Pública, 18, 413-420.

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van der Werff, J.F.A., & Ultee, J. (2000). Long term follow-up of hypospadias repair. British Journal of Plastic Surgery, 53, 588-592.

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Wakefield, J. (2001). Bad news for boys. Linking hypospadias and endocrine disruptors. Environmental Health Perspectives, 109, A 542.

Walker, M. (1998). The psychological experience of living with hypospadias through verbal descriptions and drawings. Doctoral dissertation. The Union Institute Graduate College.

Weber, R.F.A., Pierik, F.H., Dohle, G.R., & Burdof, A. (2002). Environmental influences on male reproduction. British Journal of Urology International, 89, 143-148.

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Wilcox, D.T., & Ransley, P.G. (2000). Medicolegal aspects of hypospadias. British Journal of Urology International, 86, 327-331.

Wilson, B.E., & Reiner, W.G. (1999). Management of intersex: a shifting paradigm. In A.D. Dreger (Ed.), Intersex in the age of ethics (pp.119-135). Hagerstown, Maryland: University Publishing Group.

Yoshiyuki, K., Hayashi, Y., Kentaro, M., Mogami, M., Sasaki, S., & Kohri, K. (2002). Spermatogenesis, fertility and sexual behavior in a hypospadiac mouse model. Journal of Urology, 167, 1532-1537.

Zaontz, M.R., & Packer, M.G. (1997). Abnormalities of the external genitalia. Pediatric Clinics of North America, 44, 1267-1297.

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Adresses Internet articles médicaux 

Avolio, L. (2002). Genital anomalies. e-Medicine Journal.

http://author.emedicine.com/PED/topic2798.htm

 

Bourgeois, M.J. (2002). Microphallus. e-Medicine Journal.

http://www.emedicine.com/PED/topic1448.htm 

 

Hensle, T.W., & Weiner, D.M. (2000). Hypospadias. In E.T. Goluboff (Ed.), Hospital Physician. Urology Board Review Manual, Vol. 8, Part 3. Turner-White.com.

http://www.turner-white.com/pdf/brm_Urol_V8P3_00.pdf

 

Hutcheson, J. (2002). Ambiguous genitalia and intersexuality. e-Medicine Journal.

http://author.emedicine.com/PED/topic1492.htm

 

Hutson, J.M. (2002). Cryptorchidism and hypospadias. Endotext.com

http://www.endotext.org/male/male19/male19.htm

 

Migeon, C.J., Wisniewski, A.B., Brown, T.R., Rock, J.A., Meyer-Bahlburg, H.F.L., Money, J., & Berkovitz (2002a). 46, XY Intersex Individuals: Phenotypic and etiologic classification, knowledge of condition, and satisfaction with Knowledge in adulthood. Pediatrics.

http://www.pediatrics.org/cgi/content/full/110/3/e32

 

Migeon, C.J., Wisniewski, A.B., Gearhart, J.P., Meyer-Bahlburg, H.F.L., Rock, J.A., Brown, T.R., Casella, S.J., Maret, A., Ngai, K.M., Money, J., & Berkovitz, G.D. (2002b). Ambiguous genitalia with perineoscrotal hypospadias in 46, XY individuals: Long-term medical, surgical, and psychosexual outcome. Pediatrics.

http://www.pediatrics.org/cgi/content/full/110/3/e31

 

Santanelli, F. (2002). Urogenital reconstruction, penile hypospadias. e-Medicine Journal.

http://www.emedicine.com/plastic/topic495.htm

 

Dictionaries

Garnier, M., Delamare, V., Delamare, J., & Delamare, T. (2000). Dictionnaire des termes de médecine (26ème ed.). Paris : Maloine.

Prudhomme C., & d’Ivernois, J.F.(2002). Dictionnaire des maladies à l’usage des professionnels de la santé. Paris : Maloine.